Spleen and Atherosclerosis (II)
نویسندگان
چکیده
منابع مشابه
Porcine Spleen Deoxyribonuclease II
Porcine spleen DNase II, a lysosomal acid hydrolase, is a noncovalently linked azb heterodimer (Liao, T.-H. (1985) J. Biol. Chem. 260, 10708–10713). The a subunit, after disulfide cleavage, yields two chains, a1 and a2. The complete amino acid sequences of the a1, b, and a2 chains were elucidated by protein sequencing, and the pairings of one interchain disulfide between a1 and a2 and of three ...
متن کاملEndothelial arginase II and atherosclerosis
Atherosclerotic vascular disease is the leading cause of morbidity and mortality in developed countries. While it is a complex condition resulting from numerous genetic and environmental factors, it is well recognized that oxidized low-density lipoprotein produces pro-atherogenic effects in endothelial cells (ECs) by inducing the expression of adhesion molecules, stimulating EC apoptosis, induc...
متن کاملComparison of peptides bound to spleen and thymus class II
In the past we and others have suggested that positive selection of developing thymocytes may depend upon interaction between the alpha beta receptors on these cells and major histocompatibility complex (MHC) proteins bound to peptides found uniquely in the selecting tissue, thymus cortical epithelium. To test this hypothesis, peptides were isolated from MHC class II proteins of spleen, thymus ...
متن کاملAngiotensin II amplifies macrophage-driven atherosclerosis.
OBJECTIVE We evaluated the role of angiotensin II (AII) in a marrow-derived macrophage-driven model of atherosclerosis. METHODS AND RESULTS Eight-week-old C57BL/6 wild-type mice were reconstituted with bone marrow harvested from apolipoprotein E-deficient (apoE-/---> apoE+/+) or wild-type for apoE gene (apoE+/+--> apoE+/+) mice. At 20 weeks, mice were exposed to either AII (1000 ng/kg per min...
متن کاملINTRACELLULAR LOCALIZATION OF ENZYMES IN SPLEEN II. Some Properties and the Distribution of Ribonuclease in Rat Spleen
Some properties of rat spleen ribonuclease have been studied, and the intracellular distribution of the enzyme and ribonucleic acid have been presented. Spleen ribonuclease exhibits maximal activity at pH 5.8, and although there is some evidence for the presence of an enzyme with an opt imum at pH 7.0, it is not conclusive. The enzyme is concentrated primarily in the mitochondrial fraction, but...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1987
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.15.7_1443